Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence (“arginine 3”), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (“long”), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1’s half-life of about 12–15 hours).

IGF LR3 HPLC

Compound Calculators

Specification:

Application	Insulin-Like Growth Factor 1 (IGF-1) Analogue
CAS	946870-92-4
Molar Mass	9117.5  g/mol
Chemical Formula	C400H625N111O115S
Chemical Name	(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
Synonyms	1-13-Somatotropin (swine reduced), 1-L-methionine-12-L-valine-, (13->1′)-protein with 3-L-arginine insulin-like growth factor I (human) 143045-27-6 IGF-1 LR3 Insulin-like growth factor long chain R3 Long R3 insulin-like growth factor-i Long-(arg3)insulin-like growth factor-i M9L22Y19H9
Solubility	It is recommended to reconstitute the lyophilized  powder in sterile .06% acetic acid solution, which can then be diluted to for various aqueous solutions.
Stability	water, DMSO, Ethanol
Shipping Temp	Room Temp
Physical Form	Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence	MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.

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